Claudin‐5 decreases alveolar epithelial barrier function
نویسندگان
چکیده
منابع مشابه
Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function.
The lung is the site of entry for Bacillus anthracis in inhalation anthrax, the deadliest form of the disease. Bacillus anthracis produces virulence toxins required for disease. Alveolar macrophages were considered the primary target of the Bacillus anthracis virulence factor lethal toxin because lethal toxin inhibits mouse macrophages through cleavage of MEK signaling pathway components, but w...
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Published Ahead of Print 1 October 2012. 2012, 80(12):4374. DOI: 10.1128/IAI.01011-12. Infect. Immun. Patrick Metcalf Burian, Jimmy Dale Ballard, Armin Braun and Jordan Mark Coggeshall, Shanjana Awasthi, Florea Lupu, Dennis Prenzler, Katherina Sewald, Daniel M. Williams, Kenneth Silasi-Mansat, Vijay Ramani, Tibor Zoltan Veres, Frauke Booth, Vineet Indrajit Patel, Ryan A. Zander, Robert Marybeth...
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The simplest multicellular animal organisms, coelenterates, are essentially floating intestines in the sea. More fundamentally, they are ‘barrier tubes’ that attempt to compartmentalize the environment they exist in. It is said that ontogeny recapitulates phylogeny. It is thus interesting that the blastocyst, among the earliest multicellular embryonic structures, is essentially a sac comprised ...
متن کاملClaudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury.
Intact alveolar barrier function is associated with better outcomes in acute lung injury patients; however, the regulation of alveolar epithelial paracellular transport during lung injury has not been extensively investigated. This study was undertaken to determine whether changes in tight junction claudin expression affect alveolar epithelial barrier properties and to determine the mechanisms ...
متن کاملEthanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats.
We determined that rats fed a liquid diet containing ethanol (36% of calories) for 6 wk had decreased (P < 0.05) net vectorial fluid transport and increased (P < 0.05) bidirectional protein permeability across the alveolar epithelium in vivo compared with rats fed a control diet. However, both groups increased (P < 0.05) fluid transport in response to epinephrine (10(-5) M) stimulation, indicat...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.464.1